A fluorescent probe for endogenous HOCl

Updated: Sep 3, 2021

A fluorescent probe that enables ratiometric imaging of endogenous hypochlorous acid (HOCl) in cells and tissues by two-photon microscopy is developed based on a red-emitting acetyl-benzocoumarin (AcBC) dye. An oxathiolane group in the probe reacts with HOCl to generate the AcBC dye, which involves a ratiometric fluorescence change only toward HOCl along with high sensitivity.

Title: A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

Journal: Chem. Commun., 2017, 53, 10800

https://doi.org/10.1039/c7cc05834a

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