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Total synthesis of actinophenanthroline

Total synthesis of actinophenanthroline A, a marine actinomycete within the family ofStreptomycetaceae (strain CNQ-149) is reported. Both the racemic and enantiopure actinophenanthrolineA have been synthesized with good overall yields. Highlight of the synthesis contains the classical andeconomical double Doebner–Miller reaction to access the 1,7-phenanthroline core followed by a modifiedEDCI coupling.

Title: Total synthesis of actinophenanthroline A via double Doebner–Millerreaction

Journal: Tetrahedron Letters 57 (2016) 4009–4011

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